Due to renal toxicity 20% of compounds fail during clinical stages of drug development. ciPTEC is a human renal cell line that mimics the proximal tubule cells of the kidney. These cells are a main target for drug-induced kidney injury, caused by their role in highly efficient transport of drugs and toxic compounds from the bloodstream into urine. The most relevant drug transporter proteins involved in this process are stably and functionally expressed in our cell models.
ciPTEC: the solution to reduce the risk of drug failure during the clinical phase of drug development
Cell4Pharma’s ciPTEC models are used in 30+ laboratories world-wide and used in 60+ peer-reviewed scientific publications. Moreover, the enormous amount of research has led towards a valuable basis that provided proof-of-concept to build upon further towards full validation to reduce renal adverse effect and replace animal experimentation in the future.