CellGS in collaboration with Manchester Biogel, have prepared a webinar entitled”Innovation in 3D cell culture: creating a customizable microenvironment to replicate in vivo properties of tissues” to which they invite you to participate. Which will be taught by Dr. Natasha Lewis and Dr. Dammy Olayanju.
Complex 3D cell culture models are increasingly used for preclinical and biomedical applications ranging from regenerative medicine to drug discovery and toxicological studies. However, current 3D models are hindered by the inability of the cellular microenvironment to fully provide the molecular cues that contribute to the fully developed cellular phenotype that is seen in-vivo.
Here, we present a novel approach which combines the use of PODS® and PeptiGels® technologies (PODS-PeptiGels). This combination overcomes the limitations of present 3D models by offering a more robust, physiologically-relevant microenvironment to generate an enhanced cellular phenotype. POlyhedrin Delivery System (PODS®) is a sustained release protein delivery system that incorporates cargo proteins, such as cytokines and growth factors, into a polyhedrin crystal lattice and offers advantages over soluble proteins by providing long term localized bioavailability. PeptiGels®, on the other hand, are fully synthetic biocompatible and tuneable peptide-based hydrogels that provide an ethical alternative to traditionally used animal derived matrices with minimal batch-to-batch variability.
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