All posts by Labclinics

Due to renal toxicity 20% of compounds fail during clinical stages of drug development. ciPTEC is a human renal cell line that mimics the proximal tubule cells of the kidney. These cells are a main target for drug-induced kidney injury, caused by their role in highly efficient transport of drugs and toxic compounds from the bloodstream into urine. The most relevant drug transporter proteins involved in this process are stably and functionally expressed in our cell models.

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The SNAP SARS-CoV-2 Kit uses overlapping primers to generate 345 amplicons, sized 116-255 bp (average 150 bp), along the length of the 29.9 kb viral genome and obtain 99.7% coverage of the genome. Overlapping primers ensure that novel variants are detected, even when the mutation is a dropout of genomic sequence. Comprehensive mutation detection is crucial for tracking nucleotide variants and improve understanding of virus evolution, transmission, and pathogenesis.
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