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EVlution TFF
Cell Guidance System – CellGS continuously works to offer solutions for the concentration and purification of extracellular vesicles (EVs) and other biomolecules. Their last development, the EVlution™, is a compact, affordable modular benchtop tangential flow filtration (TFF) system engineered for high-yield concentration and purification of extracellular vesicles (EVs) and other biomolecules.
Key features EVlution™:
- Switch Flow™ for low retentate volume (<10mL)
- Entirely disposable sample contact surfaces
- Affordable
- 12 pore sizes available
- Easy to use. Minimal hands-on time
- Process 1 liter of sample in 90 minutes.
Applications:
- Recovering proteins, antibodies, and EVs from cell culture media and other starting materials.
- Concentrating and purifying proteins, peptides, and nucleic acids.
- Depletion of FBS-associated EVs
- Buffer exchange (diafiltration)
Why TTF: Principles and workflow
TFF provides an effective method of size-based separation of biomolecules, including EVs. The characteristics of TFF design makes it an excellent choice for workflows at the lab scale.
Dead-end filtration passes the entire sample volume through the filter, leading to filter clogging and a low permeate rate. TFF recirculates samples across the filter surface, sweeping the filter surface to prevent clogging.
The blue path represents the flow of the sample entering through the inlet, across the TFF cartridge and looping back as retentate. The green path represents the portion of the sample that passes through the membrane and exits separately as permeate.
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