Progranulin (PGRN) is a cysteine-rich protein, composed of seven ~6kDa granulin (GRN) proteins, that shows multifunctional biological activities, including major roles in cancer, inflammation, metabolic disease and neurodegeneration. Especially as a valuable biomarker for Frontotemporal Lobar Degeneration (FTLD).. PGRN is an abundant, non-conventional, stress-induced, extracellular matrix-bound secreted growth factor-like molecule and cytoplasmic chaperone, that functions in a cellular and disease specific pattern. PGRN binds to several functionally different receptor families in a cell/tissue specific and condition/disease-dependent manner. For example, PGRN binding with TNFR and DR3 has an important anti-inflammatory role in immune cells, particularly Tregs and macrophages. PGRN/Ephrin type-A receptor 2 (EphA2) interaction is involved in the proliferative influence of PGRN. PGRN binds and activates Notch receptors, enhancing the regenerative capacity of injured neurons.
In the brain, PGRN is primarily expressed in mature neurons and microglia. Absence of progranulin in microglia causes increased production and release of multiple cytokines, suggesting that PGRN regulates microglia activation. PGRN seems to affect microglial proliferation, recruitment, differentiation, activation and phagocytosis, suggesting that PGRN plays a central role in the regulation of neuroinflammatory responses.
• Higher activity compared to tagged progranulins
• Suitable for in vitro and in vivo studies
• Reflects the native sequence with no additional amino acids
• Affinity purified
• Low endotoxin levels (<0.01EU/µg)
Product Name | Cat. No. | Product description |
anti-Progranulin (human), pAb | AG-25A-0112 | Recognizes human progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F. Works in Immunohistochemistry and Western blot applications. |
anti-Progranulin (mouse), pAb | AG-25A-0093 | Recognizes mouse progranulin. Detects a band of ~90kDa by Western blot. Weakly cross-reacts with human progranulin. Works in Western blot application. |
anti-Granulin C (human), pAb | AG-25A-0090 | Recognizes human granulin C. Detects a band of ~12kDa by Western blot. Cross-reacts with human progranulin. Works on recombinant protein in Western blot application. |
Progranulin (human) (rec.) | AG-40A-0068Y | Human progranulin (aa 1-593) is fused at the C-terminus to a FLAG®-tag. Activates ERK phosphorylation in THP-1 and MCF10A cells and induces cell migration of THP-1 monocytic leukemia cells. |
Progranulin (rat) (rec.) | AG-40A-0194 | Rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag. |
Granulin C (human) (rec.) (His) | AG-40A-0129 | Human granulin C (aa 364-430) is fused at the N-terminus to a His-tag. |
Progranulin (PGRN) shows multifunctional biological activities, including major roles in cancer, inflammation, metabolic disease and neurodegeneration, especially as a valuable biomarker for Frontotemporal Lobar Degeneration (FTLD).
AdipoGen offers a broad range of unique Progranulin tools for neuroinflammation research.
Cookie | Duration | Description |
---|---|---|
_gat | 1 minute | This cookie is installed by Google Universal Analytics to restrain request rate and thus limit the collection of data on high traffic sites. |
Cookie | Duration | Description |
---|---|---|
IDE | 1 year 24 days | Google DoubleClick IDE cookies are used to store information about how the user uses the website to present them with relevant ads and according to the user profile. |
test_cookie | 15 minutes | The test_cookie is set by doubleclick.net and is used to determine if the user's browser supports cookies. |
VISITOR_INFO1_LIVE | 5 months 27 days | A cookie set by YouTube to measure bandwidth that determines whether the user gets the new or old player interface. |
YSC | session | YSC cookie is set by Youtube and is used to track the views of embedded videos on Youtube pages. |
yt-remote-connected-devices | never | These cookies are set via embedded youtube-videos. |
yt-remote-device-id | never | These cookies are set via embedded youtube-videos. |
Cookie | Duration | Description |
---|---|---|
_ga | 2 years | The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors. |
_gat_gtag_UA_63223560_1 | 1 minute | This cookie is set by Google and is used to distinguish users. |
_gid | 1 day | Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously. |
CONSENT | 16 years 3 months 22 days 12 hours 21 minutes | These cookies are set via embedded youtube-videos. They register anonymous statistical data on for example how many times the video is displayed and what settings are used for playback.No sensitive data is collected unless you log in to your google account, in that case your choices are linked with your account, for example if you click “like” on a video. |
Cookie | Duration | Description |
---|---|---|
cookielawinfo-checkbox-advertisement | 1 year | Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category . |
cookielawinfo-checkbox-analytics | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics". |
cookielawinfo-checkbox-functional | 11 months | The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". |
cookielawinfo-checkbox-necessary | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary". |
cookielawinfo-checkbox-others | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. |
cookielawinfo-checkbox-performance | 11 months | This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance". |
viewed_cookie_policy | 11 months | The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data. |
Cookie | Duration | Description |
---|---|---|
AZWoNIeulkq | 1 day | No description |
iGfjtNO | 1 day | No description |
qWitUQ | 1 day | No description |