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Glycoselect
GlycoSeLect Ltd specialises in the development and production of Recombinant Prokaryotic Lectins (RPLs).
RPLs are glycoselective bioaffinity compounds, they recognize and bind to specific glycan structures displayed on glycoproteins and other glycosylated biomolecules.
They can therefore enable simple, fast, and efficient detection, analysis, separation, and purification of intact glycosylated biomolecules.
Unlike with traditional plant & eukaryotic lectins, RPLs production easily delivers high-quality products with consistent performance and enhanced glycan specificity and affinity. This property enables higher yields of these molecules and makes them suitable for applications in larger-scale separation and purification methods.
Products
GlycoSeLect has developed a range of RPL products exhibiting specificity and high affinity for a range of glycan epitopes displaying terminal galactose and mannose (including high mannose structures).
All RPL products display a poly-histidine tag enabling simple detection using standard conjugated anti-his detection antibodies negating a requirement for in vitro labeling (e.g. biotinylation).
Applications
- Biopharmaceutical: The diversity of solid support matrices that RPLs can be immobilized on and the easy scalability of their production, allows huge flexibility in glycoselective bioaffinity-based purification, even for large scale use.
- Diagnostic & Research: Provide a great tool for identification of novel glycan-based biomarkers and present an opportunity for new diagnostic approaches.
- Food Industry: Can be used to extract valuable glycoproteins from food industry raw material streams.
- Cosmetics: Glycans play an important role in maintaining the structure and health of the skin. They can be used as biochemical reagents in a wide range of assay formats or integrated into analytical platforms to enable the detection and analysis of glycosylated biomolecules.
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