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(+)-Aeroplysinin-1

(+)-Aeroplysinin-1

A sea sponge metabolite with diverse biological activities; induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner from 0.25-0.5 μM; blocks EGF-induced endocytosis of EGFR and EGF-dependent cell proliferation in MCF-7 cells; inhibits BAE cell proliferation and cord formation in a Matrigel™ assay; inhibits angiogenesis in a CAM assay from 1.5-3 nmol per egg; has antibacterial activity against Gram-positive bacteria; inhibits HIV-1 replication (IC50 = 14.6 μM) ,

(+)-Aeroplysinin-1

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