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Quote (+)-D-threo-PDMP (hydrochloride)
A glucosylceramide synthase inhibitor; inhibits glucosylceramide synthase by 50% at a 5 µM in an enzyme assay; the active component of racemic DL-threo-PDMP; inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells at 25 µM; inhibits B4GALT6 and prevents lactosylceramide synthesis; inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice
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Reference:
10178-10
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