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Reference: RP02370
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Category: Protein
Reference: RP02430
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Reference: RP02507
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Interleukin 20 (IL20) is a cytokine structurally related to interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in...
Reference: RP02508
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Interleukin-21 (IL21) belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control...
Reference: RP02514
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Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the...
Reference: RP02517
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Glial cell-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. GDNF, that acts via...
Reference: RP02522
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LIF, a pleiotrophic factor, is identified in multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF is capable of promoting long-term maintenance of embryonic stem...
Reference: RP02524
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Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene. IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in...
Reference: RP02525
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Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The major role of IGF-2 is as a growth promoting hormone during gestation. It is believed to be a...
Reference: RP02935LQ
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Streptavidin is purified from the bacterium Streptomyces. It has an extraordinarily high affinity for biotin and is used extensively in molecular biology and bionanotechnology as a high-affinity biotin-binding agent...
Reference: RP02936
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The ENO1 gene encodes a multifunctional enzyme that has been identified as a key component of the glycolytic pathway. ENO1 overexpression and post-translational modifications could be of diagnostic and prognostic...
Reference: RP02937LQ
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Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells...
Reference: RP02938
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Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the...
Reference: RP02941LQ
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Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve...
Reference: RP02949
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V-set and immunoglobulin domain containing 4 (VSIG4) is a type I transmembrane glycoprotein that is a B7 family-related protein and an Ig superfamily member. Mouse VSIG4 is synthesized as a 280 amino acid (aa)...
Reference: RP02951
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This protein is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a...
Reference: RP02963
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T-cell surface glycoprotein CD3 epsilon & CD3 delta chain, also known as CD3E & CD3D , are single-pass type I membrane proteins.When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals...
Reference: RP02964LQ
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Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family...
Reference: RP10001LQ
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The SIM domain contains the four SUMO interaction motifs (SIMs) of RING-finger 4 (RNF4). This SIM domain prefers binding polySUMO chains with four or more SUMOs. It is useful for enrichment of polysumolyated proteins...
Reference: RP10003LQ
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AMSH belongs to the JAMM family of deubiquitinases that are Zn2+-dependent metalloproteases. AMSH is an endosome-associating DUB that regulates endosomal sorting by deubiquitination. SMSH specifically cleaves lysine...
Reference: RP10004LQ
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The carboxyl terminus of Hsc70-interacting protein (CHIP) is an E3 ubiquitin ligase. CHIP contains two domains, one is its TPR domain on the amino terminus and the other is its U-box domain on the carboxyl terminus....
Reference: RP10007LQ
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The linear ubiquitin chains are formed by conjugating the N-terminal methionine residue of one ubiquitin with the C-teminal glycine residue of another ubiquitin. This product is expressed in E. coli as a fusion protein.
Reference: RP10008LQ
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The linear ubiquitin chains are formed by conjugating the N-terminal methionine residue of one ubiquitin with the C-teminal glycine residue of another ubiquitin. This product is expressed in E. coli as a fusion protein.
Reference: RP10009LQ
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The linear ubiquitin chains are formed by conjugating the N-terminal methionine residue of one ubiquitin with the C-teminal glycine residue of another ubiquitin. This product is expressed in E. coli as a fusion protein.
Reference: RP10012LQ
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6xHis was fused on the N-terminus of the linear polyubiquitin chain binding domain of NEMO encompassing amino acids 183-339. This fusion protein can be used for in vitro pulldown assays and for enrichment of cellular...
Reference: RP10014LQ
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6xHis-non-cleavable K63 polyUb chains are made of the 6xHis-Ub(L73P) mutant, this substitution makes the formed polyubiquitin chains to be resistant to the majority of deubiquitinating enzymes.
Reference: RP10015LQ
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6xHis-non-cleavable linear Ub4 contains a 3xHA tag followed by a TEV cleavage site after the 6xHis tag. The G76V substitution was introduced in the first five Ub moieties and the last Ub has G76. The protein was...
Reference: RP10016LQ
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6xHis-non-cleavable linear Ub6 contains a 3xHA tag followed by a TEV cleavage site after the 6xHis tag. The G76V substitution was introduced in the first five Ub moieties and the last Ub has G76. The protein was...
Reference: RP10022LQ
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6xHis was fused in the N-terminus of the two UIM domains of S5a, which specifically bind K48-linked polyubiquitin chains. This fusion protein can be used for enrichment of K48-linked polyubiquitinated proteins in cell...
Reference: RP10023LQ
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SAE1/SAE2 is the heterodimeric E1 enzyme that conjugates SUMO to protein substrates. The conjugation process is very similar to that of protein ubiquitination. SUMO is conjugated onto the catalytic cysteine residue...
Reference: RP10025LQ
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SUMO1-3 (small ubiquitin-related modifiers) are ubiquitin-like proteins that can be conjugated to substrate proteins using a cascade of enzymatic reactions. Protein sumoylation can be reversed by the sentrin-specific...
Reference: RP10026LQ
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Neural precursor cell expressed developmentally downregulated 8 (Nedd8) is a ubiquitin-like protein. Nedd8 can be conjugated on culin proteins and this modification plays a key role in activation of culin-based E3...
Reference: RP10028LQ
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SUMO (small Ub-related modifier) is a Ub-like protein. Three types of SUMO are most commonly studied, SUMO 1, SUMO 2, and SUMO 3. SUMO 2 and SUMO 3 are almost identical isoforms and thus share many functions. Like...
Reference: RP10030LQ
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SUMO (small Ub-related modifier) is a Ub-like protein. Three types of SUMO are most commonly studied, SUMO 1, SUMO 2, and SUMO 3. SUMO 2 and SUMO 3 are almost identical isoforms and thus share many functions. Like...
Reference: RP10031LQ
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6xHis was fused on the N-terminus of the lysine 63 polyubiquitin chain binding domain of TAB2 encompassing amino acids 627-693. This fusion protein can be used for in vitro pulldown assays and for enrichment of...
Reference: RP10036LQ
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UbcH10 (Ubc2C) is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. It plays a major role in the mitosis in cell cycle by binding to the anaphase-promoting...
Reference: RP10037LQ
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Ube2D1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Two other homologues of Ube2D1 exist called Ube2D2 and Ube2D3. Ube2D2 is 89% identical to the...
Reference: RP10038LQ
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Ube2D2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2D2 is 89% identical to the amino acid sequence of Ube2D1. Ube2D2 works with Mdm2 (an E3...
Reference: RP10039LQ
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Ube2D3 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2D3 is 88% identical to the amino acid sequence of Ube2D1. Ube2D3 works with Mdm2 (an E3...
Reference: RP10040LQ
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Ube2D4 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2D4 has been linked to cadminum toxicity. It might also play a role in LDL cholesterol...
Reference: RP10042LQ
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Ube2E2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. It shares 96% identical amino acid sequence with Ube2E1 and Ube2E3 with the exception of the...
Reference: RP10043LQ
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Ube2E3 (also known as UbcH9) is an E2 enzyme, which is part of the E1, E2, E3 cascade that is responsible for ubiquitination of protein substrates. It has been found to interact with the E3 enzyme Nedd4-2 in order to...
Reference: RP10045LQ
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Ube2G1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2G1 has been shown to work in conjunction with CRL4, an E3 ligase, to ubiquitinate and...
Reference: RP10046LQ
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Ube2G2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. It has been shown to complex with the E3 ligase called GP78 to catalyze K48 – linked Ub...
Reference: RP10047LQ
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Ube2H is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2H is the human homolog to its yeast counterpart, Ubc8. Ube2H ubiquitinates histone H2A in...
Reference: RP10048LQ
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Ube2I (Ubc9) is an E2 enzyme in the E1, E2, and E3 cascade to link SUMO to a substrate. This E2 shares a similar sequence and structure to the Ub E2s and is the only known SUMO conjugating enzyme at this time. Ube2I...
Reference: RP10049LQ
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UbE2J1 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. UBE2J1 is a membrane protein localized on the endoplasmic reticulum (ER), where it catalyzes...
Reference: RP10051LQ
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Ube2L6 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. One function of this E2 is that it is involved in ubiquitination and degradation of a neuron...
Reference: RP10053LQ
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Ube2N (UbcH13/Uev1a) is a complex that acts as an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Uev1a must interact with Ubc13 because it lacks the...
Reference: RP10054LQ
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Ube2Q2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2Q2 is thought to play a key role in regulating mitotic stages in cells. Its discovery was...
Reference: RP10055LQ
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Ube2R1 (UbcH3) is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2R1 was first discovered during screening for cell cycle regulatory mutations that...
Reference: RP10059LQ
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Ube2T is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2T interacts with the E3 ligase called Fanconi anemia complementation group L (FANCL) that...
Reference: RP10060LQ
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Ube2V2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2V2 is the human homolog of yeast Mms2 and shares 50% amino acid sequence identity. Its...
Reference: RP10061LQ
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Ube2W is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. It has been shown to catalyze monoubiquitination of Fanconi anemia complementation group L...
Reference: RP10062LQ
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Ube2Z is a member of the ubiquitin conjugating enzyme (E2) that specifically works with UBA6 (UBE1L2), but not UBE1, to transfer ubiquitin or the ubiquitin-like protein FAT10 to substrates. It is involved in...
Reference: RP10064LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10065LQ
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Ubiquitin (+1) consists of the first 75 amino acids of ubiquitin, but lacks glycine 76 because of the deletion of two of the three nucleotides that encode glycine 76. The resulting frame shift leads to the addition of...
Reference: RP10067LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10068LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10070LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10071LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10072LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10073LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10074LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10075LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10078LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10079LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10080LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10082LQ
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Ubiquitin (Ub) is a 76 amino acid protein widely expressed in the cytoplasmic and nucleus of cells. Ub is posttranslationally conjugated to proteins by the E1, E2, E3 protein ubiquitination cascade. Ub can be...
Reference: RP10083LQ
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Ub75 lacks the amino acid glycine 76, which is required to form thioester bond with Ub activating enzyme E1. Therefore, Ub75 can not react with E1, E2 and E3 enzymes; and does not support ubiquitination. It can be...
Reference: RP10084LQ
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Uch37 is one of the deubiquitinating enzymes of the human 26S proteasome, belongs to the Ub C-terminal hydrolases. Uch37 was found to bind both Adrm1 and S5a subunits of the 26S proteasome. Uch37 likely contributes...
Reference: RP10088LQ
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APPBP1/UBA3 is the heterodimeric E1 enzyme that conjugates Nedd8 to protein substrates. Nedd8 is conjugated onto the catalytic cysteine residue of UBA3 by formation of a thioester bond in an ATP-dependent reaction....
Reference: RP10090LQ
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Cezanne (also called OTUD7B) is an ovarian tumor protein (OUT)-domain containing deubiquitinase that preferentially cleaves lysine 11-linked polyubiquitin, also exhibits activity for lysine 48 or lysine 63-linked...