OPG Polyclonal Antibody

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF1/TRAIL and protect against apoptosis. TNFSF1/TRAIL binding blocks the inhibition of osteoclastogenesis.
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Reference:
GRP240
Brand:
Product Details
GRP240

Data sheet

Size
100 ul
Conjugation
Unconjugated
Host
Rabbit
Clonality
Polyclonal
Reactivity
Human,Mouse,Rat
Application
IHC-P,WB

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