Anti-Granzyme B FITC

Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.
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Reference:
GRP13258
Brand:
Product Details
GRP13258

Data sheet

Size
100 Tests
Reactivity
Human,Primate
Clone
CLB-GB11
Application
FC

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