p53 Monoclonal Antibody (Clone BP53-12)

Epitope: Binds to N-terminal amino acids 16-25 of wild-type and mutant p53 • Host: Mouse • Clone: BP53-12 • Isotype: IgG2a • Species Reactivity: (+) Human and mouse; other species not tested • Applications: FC, IHC (paraffin-embedded tissue), IP, and WB • Cellular p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (DNA damage, hypoxia, heat shock, etc.) and acts to prevent further proliferation of the stressed cell by induction of cell cycle arrest or apoptotic mediators.