S1P1 Polyclonal Antibody

Immunogen: Peptide from an internal cytoplasmic region of human S1P1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, porcine, and rat S1P1 • Application(s): IF, IHC, and WB • S1P exerts its activity by binding to five distinct GPCRs, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 primarily mediates S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor.