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Quote CaMKII Monoclonal Antibody (Clone 6G9)
Antigen: rat recombinant CaMKII • Host: mouse, clone 6G9 • Isotype: IgG1 • Cross Reactivity: (+) mouse, rat, and bovine CaMKII • Application(s): ELISA, IF, IHC, IP, and WB • CaMKII functions in neural synaptic stimulation and T cell receptor signaling. The binding of Ca2+/calmodulin to its regulatory domain releases its auto inhibitory effect and activates the kinase. This kinase activation results in autophosphorylation at Thr286. PP1 dephosphorylates phospho-CaMKII at Thr286 and PKA prevents this dephosphorylation.
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Reference:
10011437-100
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