FluoBolt™-ASPORIN

Asporin is a 380 amino acid long, secreted dimeric extracellular matrix protein, which functions as a direct binding partner for TGFβ-1 and, like Decorin and Biglycan, belongs to the der Small Leucine- Rich Proteins (SLRP) class I family. They are characterised by a high degree of homology at the genetic and molecular level and the presence of leucine- rich repeats (LRRs), which are flanked by disulfides formed by cysteine residues. Unlike other members of the SLRP class II family, Asporin does not contain a glycosaminoglycan binding site, but it has several unique aspartic acid repeats in the N-Terminal region. The main biological function of Asporin most likely consists in the regulation of TGF-β1 activity to which it binds directly