FluoBolt™-KLOTHO

α-KLOTHO is a protein belonging to the glycosyl hydrolase 1 family. It can be found either as a membrane bound or a secreted form, which is the more abundant form. α-KLOTHO is expressed in kidney, small intestine, placenta and prostate. The soluble peptide can be found in serum and cerebrospinal fluid. KLOTHO is a co-receptor of fibroblast growth factor 23 (FGF-23) and it plays an important role in the calcium/ phosphorus homeostasis regulation by e.g. inhibiting active vitamin D synthesis. Further, it is also known as an anti-aging-hormone by extending life span by inhibiting insulin/ IGF1 signaling pathway, as experiments in mice showed. Although there are some assay systems for measuring α-KLOTHO available, current existing clinical data is noncoherent. Therefore, we decided to use our FluoBolt™-Technology to provide a high sensitivity α-KLOTHO assay for clinical research, that may improve data consistency.