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Quote Decitabine
Experiments have shown that this compound induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits DNA methyltransferase. DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to Decitabine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin.
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SM46-50
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