Wortmannin

Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Similar potency in vitro for the class I, II, and III PI3K. Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor, regardless of the nutrient status and thus is a more suitable autophagy inhibitor than 3-MA. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. TRAIL sensitizer