Fostriecin

Antibiotic. Anticancer compound. Antifungal. Catalytic inhibitor of topoisomerase II (IC50 = 40 µM). Potent protein phosphatase 2A (PP2A) (IC50 = 1.5 nM) and 4 (PP4) (IC50 = 3 nM) inhibitor. Weak protein phosphatase type 1 (PP1) inhibitor (IC50=131µM). No apparent inhibition on PP2B. Mitotic entry checkpoint inhibitor. Mediates cell cycle arrest at G2-M-phase. Ischemia protective. The PP2A binding site is different from that of okadaic acid
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Reference:
AG-CN2-0057-C010
Brand:
Product Details
AG-CN2-0057-C010

Data sheet

Size
10 ug
Host
Isolated from Streptomyces pulveraceous subsp. fostreus.
CAS
87860-39-7
URL - Product
https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/12161

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