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Quote Colistin sulfate (USP Grade)
Very potent polymyxin antibiotic. Has only one amino acid difference compared to polymyxin B. Antimicrobial. Targets the lipopolysaccharide (LPS) of the outer membrane of Gram-negative bacteria. Competitively displaces divalent cations (Ca2+ and Mg2+) from the negatively-charged phosphate groups LPS, causing disruption of the membrane. This increases the permeability of the cell envelope, leakage of cell contents, leading to apoptosis and cell death. Used against multidrug-resistant Gram-negative bacterial infections.
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Reference:
AG-CN2-0065-G001
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