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Quote Purpuromycin
Rubromycin antibiotic. Antibacterial, antifungal and anti-protozoal agent. Active against Gram-positive bacteria, Gram-negative bacteria and fungi. Telomerase inhibitor (IC50=3µM). Protein synthesis inhibitor. Binds tRNAs with high affinity and specifically inhibits aminoacyl-tRNA formation consequent inhibition of protein synthesis in these microorganisms. Inhibits of all tRNA synthetases. Effectively inhibits bacterial translation and translation in eukaryotic cells. Modest inhibitor of retroviral reverse transcriptase.
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Reference:
AG-CN2-0317-M025
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