In humans, there are 25 selenoproteins coding genes. This proteins are involved in diverse metabolic and physiological functions ranging from antioxidant defense to fertility, muscle development and function, thyroid hormone metabolism, and immune function. Several selenoproteins also have major importance in cancer, both as enzymes protecting cells from carcinogenesis and as target proteins for anticancer drug therapies. Consequently, the range of pathologies associated with primary or secondary defects in selenoprotein functions are many.
All selenoproteins contain a rare amino acid, selenocysteine, which has limited their use in research, therapy, and diagnosis. Until now, customers have been forced to purchase inactive selenoproteins, which lack the essential selenocysteine residue, or active selenoproteins obtained from animal sources, which are expensive, ethically questionable, and provide very low yields.
Labclinics offers an extensive catalog of these active selenoproteins. And thanks to Selenozyme we could produce any of the more than 800 natural selenoproteins identified so far in nature, or any synthetic protein containing selenocysteine on demand.
If you are interested in the synthesis of any selenoprotein or any synthetic protein with selenocysteine, contact us: