arigo offers Antibody Duo and Antibody Panel products for researchers who work on various research topics. These are the featured duos, but check out the catalog to see them all.
In multicellular organisms, cells no longer needed or have become a threat to the organism will be destroyed by a tightly regulated suicide mechanism called programmed cell death, or more commonly known as Apoptosis.
Apoptosis process involves a cascade of proteolytic cleavage of Caspase molecules. Apoptosis can be initiated by intra- or extracellular death signals and the regulation of apoptosis can involve a wide variety of molecules.
Recomended Duo : Apoptosis Marker Antibody Duo (Caspase 3, PARP)
The TUNEL assay has been commonly used as a detection method for identifying apoptotic cells. While useful, it can also yield highly variable results as some non-apoptotic nuclei showing high levels of RNA synthesis/splicing can also be labeled by TUNEL technique.
Cleavage of Caspase 3 and PARP (Poly (ADP-ribose) Polymerase is a pre-requisite for cells who undergo final stage of cell death. The use of anti-cleaved caspase3 and anti-cleaved PARP antibodies adds a more specific weapon to the arsenal of techniques for confirming apoptosis in tissue specimens.
Constitutively active GSK-3 acts to destabilize beta catenin through phosphorylation (Ser37), thus, functioning as a tumor suppressor to limit proliferation. In contrast, GSK-3 promotes expansion of leukemic cells transformed by HOX overexpression through phosphorylation of CREB (Ser133) and subsequent formation of a transcriptional coactivator complex.
Recomended Duo: Phospho-CREB (pS133)/Phospho beta-Catenin (pS37) Antibody Duo
Arigo provides CREB / beta Catenin phospho Duos, ARG30024, which include beta catenin (phosphor Ser37) antibody and CREB (phosphor Ser133) antibody for researchers to analysis the downstream protein and the pathway of active-GSK-3
If you need more information about how Arigo can help you with your research or a budget, do not hesitate to contact us:
|_gat||1 minute||This cookie is installed by Google Universal Analytics to restrain request rate and thus limit the collection of data on high traffic sites.|
|IDE||1 year 24 days||Google DoubleClick IDE cookies are used to store information about how the user uses the website to present them with relevant ads and according to the user profile.|
|test_cookie||15 minutes||The test_cookie is set by doubleclick.net and is used to determine if the user's browser supports cookies.|
|VISITOR_INFO1_LIVE||5 months 27 days||A cookie set by YouTube to measure bandwidth that determines whether the user gets the new or old player interface.|
|YSC||session||YSC cookie is set by Youtube and is used to track the views of embedded videos on Youtube pages.|
|yt-remote-connected-devices||never||These cookies are set via embedded youtube-videos.|
|yt-remote-device-id||never||These cookies are set via embedded youtube-videos.|
|_ga||2 years||The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.|
|_gat_gtag_UA_63223560_1||1 minute||This cookie is set by Google and is used to distinguish users.|
|_gid||1 day||Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.|
|CONSENT||16 years 3 months 22 days 12 hours 21 minutes||These cookies are set via embedded youtube-videos. They register anonymous statistical data on for example how many times the video is displayed and what settings are used for playback.No sensitive data is collected unless you log in to your google account, in that case your choices are linked with your account, for example if you click “like” on a video.|
|cookielawinfo-checkbox-advertisement||1 year||Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .|
|cookielawinfo-checkbox-analytics||11 months||This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".|
|cookielawinfo-checkbox-functional||11 months||The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".|
|cookielawinfo-checkbox-necessary||11 months||This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".|
|cookielawinfo-checkbox-others||11 months||This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.|
|cookielawinfo-checkbox-performance||11 months||This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".|
|AZWoNIeulkq||1 day||No description|
|iGfjtNO||1 day||No description|
|qWitUQ||1 day||No description|