GeneTex, Inc. has hosted an exciting new webinar titled, “From Skin to Brain: The Epigenetic Basis of Inflammatory Training“, taught by Dr. Samantha B. Larsen, in which she will talk about inflammatory training and tissue repair, and the long-term consequences of inflammation in the brain. As well as, of brain injuries and the treatment and prevention of injury-induced neuropathogenesis.
Inflammatory training is the generation of an epigenetic memory that leads to an augmented state of responsiveness to a broad range of secondary stimuli. Though previously thought to be exclusive to the innate immune system, Dr. amantha Larsen discovered that epithelial stem cells can undergo inflammatory training that accelerates tissue repair. She revealed this phenomenon hinges on the coordinated efforts of stimulus-specific, stress-responsive, and homeostatic transcription factors that extend to diverse stimuli, cell types, and species. She has now extended her interests in the long-term consequences of inflammation to the brain, where she has identified that neurons, much like other long-lived cell types, undergo inflammatory training that may predispose them to subsequent neurodegeneration. Moving forward, she is addressing the persistent transcriptional and electrophysiological changes that follow concussive brain injury with the ultimate goal of treating and preventing injury-induced neuropathogenesis.